Development of novel regenerative medicine using skull-derived mesenchymal stem cells in spinal cord injury

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K18392
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56010:Neurosurgery-related
• Research Institution: Hiroshima University
• Principal Investigator: Abiko Masaru 広島大学, 医系科学研究科(医), 研究員 (50837804)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 間葉系細胞

Outline of Final Research Achievements

In this study, we planned to verify following 4 matters: (1) establishment of optimal conditions for cell transplantation to a rat spinal cord injury model, (2) verification of motor function improvement effects in different transplanted cells, (3) search for genes that contribute to recovery and verification of relevance to motor function improvement , and (4) verification of histological improvement effect in differences in cell transplantation. Regarding (1), when MSCs derived from the rat skull were transplanted into spinal cord injury model rats, a favorable functional improvement effect was shown. (2) Subsequent verification could not be performed due to various events such as changes in the researcher's work environment.

Free Research Field

脳神経外科学

Academic Significance and Societal Importance of the Research Achievements

ラット脊髄損傷モデルに対して頭蓋骨由来MSCsを用いた再生医療が運動機能改善に与える効果を検討し、その作用機序について明らかにすることを目的とした。また、その成果によりヒト頭蓋骨由来MSCsを用いた脊髄損傷に対する新たな再生医療の開発および臨床応用を目指し、社会のニーズに応えることを目指した。