Investigation of the mechanism of aquaporin 1 expression in malignant glioma and new target potential by regulation of AQP1

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K18420
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56010:Neurosurgery-related
• Research Institution: Kanazawa University
• Principal Investigator: Masahiro Oishi 金沢大学, 附属病院, 特任助教 (50646693)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: アクアポリン１ / 悪性神経膠腫 / Glioblastoma / 血管新生 / THSD7A / 浸潤 / AQP1

Outline of Final Research Achievements

The aim of this research is to reveal the mechanism of AQP1 expression in malignant glioma. Regulation of AQP1 expression and function by AQP1 inhibitors may be a new therapeutic approach to control proliferation and invasion associated with angiogenesis.
In our previous project, we found that glucose metabolism increases AQP1 expression in GBM, and that increased AQP1 expression enhances GBM invasion and migration, and may promote angiogenesis by suppressing THSD7A, an angiogenesis inhibitor. In this research, we confirmed that several molecules involved in invasion and migration are upregulated in a dose-dependent manner with AQP1 expression level. We published the results of our study in Cancer Med. 2020 Jun;9(11):3904-3917.

Free Research Field

脳神経外科

Academic Significance and Societal Importance of the Research Achievements

悪性神経膠腫の研究は世界中で多くなされている現在においても、予後不良な脳腫瘍である。既存の概念に囚われない、新規治療法の開発が必要不可欠であり、腫瘍の増殖・進展に関わる分子メカニズムの解明は重要である。悪性神経膠腫とAQP1に関連した報告は少なく、本研究を論文として発表できたことは、腫瘍の悪性度に関わるメカニズム解明の一助になったと考えられる。