Development of a new diagnostic method for brain injury after subarachnoid hemorrhage targeting matricellular protein

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K18423
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56010:Neurosurgery-related
• Research Institution: Mie University
• Principal Investigator: Nishikawa Hirofumi 三重大学, 医学部附属病院, 助教 (10582116)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: くも膜下出血 / 早期脳損傷

Outline of Final Research Achievements

In order to improve the prognosis of subarachnoid hemorrhage (SAH) due to cerebral aneurysm rupture, it is necessary to accurately and early diagnose microcirculatory disturbance following SAH-specific early brain injury (EBI), in addition to cerebral vasospasm which has been the focus of attention in the past. Early diagnosis allows us to treat them at an early stage. However, there are currently no diagnostic methods for EBI-related pathologies that may lead to delayed brain damage. Therefore, the relationships between a group of proteins collectively called matricellular protein, which is a special extracellular matrix protein, and EBI-related pathologies were clarified in SAH models. In addition, matricellular proteins were measured in the peripheral blood in SAH patients, and basic data were obtained to use the matricellular proteins as biomarkers reflecting EBI-related pathologies and cerebral vasospasm, and to develop a new diagnostic method for EBI-related pathologies.

Free Research Field

脳血管障害

Academic Significance and Societal Importance of the Research Achievements

本研究結果は、脳動脈瘤破裂によるくも膜下出血発症後３日以内の急性期に測定する複数の血中マトリセルラー蛋白濃度単独あるいは組み合わせにより、その後に生じる遅発性脳損傷の原因病態を特定するための重要な基礎データになる。これらのデータはマトリセルラー蛋白測定診断キットの開発につながる可能性を秘めており、従来、不可能であったくも膜下出血後の遅発性脳損傷の早期診断法の確立に発展可能と考える。また、将来的には遅発性脳損傷の病態に応じた個別化治療が初めて可能となり、くも膜下出血の予後改善に繋がることが期待できる。