comprehencive search for metabolomics-based biomarker for predicting the appearance of symptom in the patients with asymptomatic carotid artery stenosis

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K18428
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56010:Neurosurgery-related
• Research Institution: Kobe University
• Principal Investigator: Yamashita Shunsuke 神戸大学, 医学研究科, 医学研究員 (80839572)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: 頚動脈狭窄症 / 脳血管反応性

Outline of Final Research Achievements

ICA-selective MRA and VA-selective MRA constructed by Beam SAT pulse is useful for evaluating the presence of collateral flows via the circle of Willis in the patients with cervical internal carotid artery stenosis. The presence of collateral flows via the circle of Willis was associated with reduced cerebrovascular reactivity of the ipsilateral middle cerebral artery territory. Evaluating the collateral flows via the circle of Willis on ICA- and VA-selective MRA may be helpful for predicting hemodynamic status on SPECT.

Free Research Field

脳血管障害

Academic Significance and Societal Importance of the Research Achievements

脳血管反応性の低下は、頚動脈狭窄症に対する血行再建術後の過灌流症候群の危険因子と考えられている。脳血管反応性の精査にはPETやSPECTなどの核医学検査が行われるが、被曝等の問題がある。本研究では、BeamSAT pulseを利用したICA-selective MRAおよびVA-selective MRAを用いてウィリス動脈輪を介したcross flowを評価し、脳血管反応性との相関が認められたが、侵襲度の低いMRIによって脳血管反応性の低下を検出できる可能性があると考える。