Basic research on long-term nerve regeneration without depletion of neural stem cells in the damaged hippocampus.

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K18438
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56010:Neurosurgery-related
• Research Institution: Keio University
• Principal Investigator: KASE Yoshitaka 慶應義塾大学, 医学部(信濃町), 助教 (00830655)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 神経突起 / ニューロン / 老化 / p38

Outline of Final Research Achievements

RK-682, which can maintain p38 activity, has been shown to elongate neurites of human iPS cell-derived neurons. It is known that neurites degenerate due to aging and neurodegenerative diseases, for which RK-682 may be useful.
In addition, RK-682 may be useful in regenerative medicine for brain injury by transplantation of neural stem cells, since RK-682 can elongate neurites after transplantation by adding RK-682 to neural stem cells in advance.

Free Research Field

神経科学

Academic Significance and Societal Importance of the Research Achievements

本研究でRK-682はp38のリン酸化活性の維持を介して、神経突起伸長に寄与することが明らかとなった。老化に限らず、神経変性疾患では軸索変性が認められることから、RK-682は神経変性疾患に対しても有効である可能性がある。