Adipose-derived mesenchymal stromal cells transplantation for severe spinal cord injury and the mechanism of therapeutic effect

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K18457
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56020:Orthopedics-related
• Research Institution: University of Fukui
• Principal Investigator: Takahashi Ai 福井大学, 学術研究院医学系部門(附属病院部), 助教 (90615303)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: 脊髄損傷 / 脂肪由来間葉系間質細胞 / 酸化ストレス

Outline of Final Research Achievements

Adipose-derived mesenchymal stem cells (AD-MSCs) are a new transplantation material that is relatively easy to harvest. We have previously reported that AD-MSCs are more resistant to hypoxic conditions and oxidative stress than bone marrow stromal cells, have better survival rate after transplantation, and improve motor function, nerve regeneration, and angiogenesis after transplantation. In this study, we reported that (1) AD-MSC transplantation combined with treadmill training can improve motor function in severe spinal cord injury, and (2) the synthetic capacity of VEGF and CCL2 is increased under oxidative stress.

Free Research Field

整形外科学関連

Academic Significance and Societal Importance of the Research Achievements

脊髄損傷は高所転落などによる高エネルギー外傷に加え，転倒などの軽微な外傷で生じることが多い。重度脊髄損傷では永続的な麻痺か感覚障害を発症し，ADLの低下を招く。脊髄損傷の治療法として，脂肪由来間葉系間質細胞の移植が治療効果を有すると考えられており，本研究では治療効果と効果の機序を検証するものである。