Changing in material structure of anti-oxidant doped highly cross-linked polyethylene retrieved from in vivo

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K18462
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56020:Orthopedics-related
• Research Institution: Mie University
• Principal Investigator: Tone Shine 三重大学, 医学部附属病院, 助教 (80763739)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 人工関節置換術 / ポリエチレン / インサート / ライナー / 酸化度 / 酸化誘導時間

Outline of Final Research Achievements

This research investigated the oxidative degradation of highly crosslinked polyethylene (HXLPE) with doped antioxidants, which was retrieved from in vivo after total hip and knee arthroplasty. The study included 20 cases of HXLPE with antioxidants among the second-generation HXLPEs that were retrieved from in vivo after total hip and knee arthroplasty. The researchers measured the maximum oxidation index and oxidative induction time. The findings revealed that the oxidative induction time was significantly correlated with the vitamin E index, resulting in higher oxidation resistance in antioxidant infused HXLPE compared to antioxidant blended HXLPE. However, the maximum oxidation index showed a significant correlation with the duration of in vivo time, indicating that oxidative degradation may occur even when antioxidants are doped.

Free Research Field

整形外科

Academic Significance and Societal Importance of the Research Achievements

抗酸化剤添加高度架橋型ポリエチレンにおいては実験的に高い酸化能を有することが報告されている。しかしながら、本研究において酸化能は生体内の留置期間に伴って徐々に減少していき、生体内留置期間に沿って酸化度が上昇することが示された。これは人工関節の耐久性に影響する可能性があり、学術的・臨床的に非常に重要な結果である。今後はさらに長期間体内に留置されたサンプルについてさらなる検討が必要と考えられる。