2021 Fiscal Year Final Research Report
A study exploring the possibility of correcting ligament ossification by early intervention in glucose metabolism disorders
| Project/Area Number |
19K18512
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 56020:Orthopedics-related
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| Research Institution | Aichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | びまん性特発性骨増殖症 / 糖尿病 / 骨代謝 / 糖代謝 / 靱帯骨化 |
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| Outline of Final Research Achievements |
1) A database could be accumulated and CT3D analysis software was purchased for the construction of new diagnostic criteria that are quantitative and have little error between examiners for ligament ossification (DISH). However, since 3D analysis of images requires time and effort, the number of cases for which results can be derived has not been reached and analysis is continuing. 2) Regarding the elucidation of the effect of the presence of abnormal glucose metabolism on ligament ossification and extension, data collection methods are from the usual clinical practice and the number of patients with ligament ossification is small, so data collection is continuing. 3) Experiments on the involvement of insulin in ligament ossification by the use of insulin sensitizers in rats with spontaneous ligament ossification have been put on hold due to difficulty in securing research materials and collaborators.
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| Free Research Field |
整形外科
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は整形外科領域に関わる骨代謝異常と糖代謝異常の双方の早期診断および介入の長期的有効性を確立し高齢年代におけるADL維持・QOL向上を目指して整形外科領域に関わる骨代謝異常と糖代謝異常との相関を解明する事を目的としているが、現段階では学術的意義や社会的意義を示せるまでの成果には至っていない。
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