The Effect of Hyperbaric Oxygen Therapy on Joint Swelling in Patients after Artificial Knee Arthroplasty

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K18526
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56020:Orthopedics-related
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Ohara Toshiyuki 東京医科歯科大学, 東京医科歯科大学病院, 助教 (00793001)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 高気圧酸素治療 / 人工膝関節手術 / 軟部組織腫脹

Outline of Final Research Achievements

Osteoarthritis of the knee can be treated by total knee arthroplasty (TKA) to eliminate pain, correct deformity, restore range of motion, and improve ADL and quality of life, but postoperative soft tissue swelling has been treated mainly by rest and icing. The purpose of this study was to investigate whether hyperbaric oxygen therapy, in which hyperbaric oxygen is inhaled at 2 ATA or higher to increase the amount of dissolved oxygen, could reduce swelling in soft tissue swelling and circulatory disturbance. Hyperbaric oxygen therapy was suspended from April 2020 due to COVID19, and the staffing was greatly restricted due to infection control measures, making it impossible to recruit patients during this period.

Free Research Field

高気圧酸素治療　膝関節外科

Academic Significance and Societal Importance of the Research Achievements

人工膝関節置換術(TKA)後の膝関節周囲軟部組織の腫脹は、これまで安静やアイシングによる対症療法が主であった。高気圧酸素治療(HBO)による術後介入により、学術的にはこれまでに存在しない整形外科待機的手術に対するHBOの有効性を示し、後療法の選択肢を増やすことができること、社会的にはリハビリ期間や入院期間の短縮、術前以上のADLへの早期復帰を可能にすることでの医療経済の負担軽減を示す予定であった。しかしCOVID19の影響により、2020年4月から高気圧酸素治療は、感染対策のために大きく人員を制限した治療をせざるを得ず、期間中の症例リクルートは不可能であった。