In Vivo biomechanical evaluations of Internal bracing with an artificial ligament for repairing grade 3 superficial medial collateral ligament injury in a porcine model.

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K18539
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56020:Orthopedics-related
• Research Institution: Jichi Medical University
• Principal Investigator: TAKAHASHI Tsuneari 自治医科大学, 医学部, 講師 (80781301)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 膝内側側副靭帯損傷 / 補強修復術 / 生体工学的研究 / 大動物モデル

Outline of Final Research Achievements

We used a porcine model to evaluate the efficacy of internal bracing using an artificial ligament for the early repair of acute, grade 3 sMCL injuries. As Results, significant differences in failure mode were observed among the three groups. All sMCLs repaired with just the suture anchors (Group R) were avulsed from the femoral attachment, while most of the sMCLs repaired with internal bracing augmentation (Group IB) exhibited mid-substance tears (Group R vs Group IB, P = 0.0023). In Group S, 14 sMCLs were avulsed from the femoral attachment and two were avulsed from the tibial attachment (Group IB vs Group S, P < 0.001). No significant difference was observed between Group R and Group S. There were no significant differences in the upper yield load, maximum load, linear stiffness, or elongation at failure among the groups.
These findings indicated that loading of an artificial ligament for internal bracing did not result in better structural properties of the repaired sMCL itself.

Free Research Field

整形外科科学

Academic Significance and Societal Importance of the Research Achievements

人工靭帯を用いた内側側副靭帯補強修復術の臨床成績に関する報告は少なく、大動物を用いた生体力学的研究の報告も無かったため、本研究は膝内側側副靭帯損傷モデルに対する人工靭帯を用いた補強修復術のin vivo studyとして初の報告となり、臨床的意義が強いと考えられる。 本研究の結果はヒト内側側副靭帯重度損傷に対する自家腱採取の侵襲を低減した新規手術治療法の開発の基盤となる可能性がある。