Role of Hippo Pathway Regulation by the Peritumoral Microenvironment in Castration-resistant Prostate Cancer

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K18551
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56030:Urology-related
• Research Institution: Akita University
• Principal Investigator: Nara Taketoshi 秋田大学, 医学部附属病院, 助教 (00801888)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 前立腺癌 / 癌周囲微小環境 / Hippo経路

Outline of Final Research Achievements

We assess the relationship among diet, gut microbiota, lipid metabolism and immune microenvironment during diet induced prostate cancer progression. We found that saturated and/or mono-unsaturated fatty acid promotes prostate cancer progression with alteration of orders Clostridales and Lactobacillales and modulation of cholesterol/lipid metabolism in prostate tumors.

Free Research Field

前立腺癌

Academic Significance and Societal Importance of the Research Achievements

特定の脂質摂取の前立腺癌増悪・進展への分子生物学的関係性が明らかになると、これまで同定されていなかった新規の前立腺癌治療標的発見の足掛かりになるのみならず、食事や肥満といった生活因子や腸内細菌変動による癌治療や癌予防戦略につながる可能性があると考えている。