2020 Fiscal Year Final Research Report
Elucidation of the function and role of Ovol2 / MOVO in spermatogenesis
| Project/Area Number |
19K18574
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 56030:Urology-related
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| Research Institution | Kansai Medical University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2021-03-31
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| Keywords | Ovol2 / 精子形成 / 男性不妊 |
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| Outline of Final Research Achievements |
In this study, we attempted to analyze the phenotype of conditional knockout mice lacking the expression of the Ovol2 / MOVO gene. The pregnancy rate of male mice with Ovol1 / Ovol2 double conditional knockout was not significantly different from that of the wild type. Testis weight was significantly lower in Ovol1 / Ovol2 double conditional knockout mice than in wild-type and non-Ovol1 conditional knockout mice. Therefore, it was suggested that Ovol2 has some involvement in spermatogenesis.
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| Free Research Field |
男性学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究はOvol2/MOVO遺伝子が精子形成にいかに関与するかを検討したものである。動物実験の結果、Ovol2欠損マウスは野生型と比べて妊娠率には差を認めなかったものの、精巣重量が有意に低下するという結果になった。このことは近年男性不妊の原因の一つである、乏精子症に関連する可能性もある。引き続き、Ovol2が精子形成に与える役割について検討を行う予定である。
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