2020 Fiscal Year Final Research Report
Association of androgen receptor signal, radiosensitivity and DNA repair pathway in urothelial carcinoma
Project/Area Number |
19K18621
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 56030:Urology-related
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Research Institution | Keio University |
Principal Investigator |
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Project Period (FY) |
2019-04-01 – 2021-03-31
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Keywords | 尿路上皮癌 / PARP阻害剤 / DNA修復機構 / アンドロゲン受容体 |
Outline of Final Research Achievements |
We examined the efficacy of combination therapy with anti-androgenic agent, radiotherapy and PARP inhibitor for bladder cancer cell line: 5637 with androgen receptor expression. 5637-AR cells revealed anti-androgenic agent and PARP inhibitor enhanced radiosensitivity. Combined administration of PARP inhibitor and anti-androgenic agent didn’t showed higher anti-tumor effect than single agent.
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Free Research Field |
尿路上皮癌
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Academic Significance and Societal Importance of the Research Achievements |
PARP阻害剤は実臨床において卵巣癌、乳癌、前立腺癌、膵癌に適応があり、本研究ではPARP阻害剤の膀胱癌における有効性について検証した。
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