Prognostication of Ovarian Function after Ovarian Torsion Using Intraoperative Indocyanine Green Angiography

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K18636
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56040:Obstetrics and gynecology-related
• Research Institution: University of Yamanashi
• Principal Investigator: Oyama Keisuke 山梨大学, 大学院総合研究部, 臨床助教 (90833624)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: ischemia / near field angiography / ovarian necrosis

Outline of Final Research Achievements

A method that predicts how much of the ovarian reserve capacity remains after detorsion of an accidentally twisted ovary has not yet been determined. Currently, treatment choices in clinical cases have been based on subjective estimations, including the “color” of the ovary during surgery or the policy of “preserving the ovaries for all cases.” In our study, the fact that indocyanine green angiography can quantitatively evaluate ovarian torsion during surgery and that maximum fluorescence value before releasing ischemia and the reperfusion rate (maximum fluorescence value after releasing ischemia / maximum fluorescence value before releasing ischemia) are useful parameters for predicting the prognosis were significant findings.

Free Research Field

Obstetrics and Gynecology

Academic Significance and Societal Importance of the Research Achievements

学術的意義は、これまで確立されていなかった卵巣の定量的血流評価を見出したことである。さらに、卵巣の機能温存に必要な、虚血に陥った卵巣の血流量や、虚血解除した瞬間の再灌流の程度が、他の臓器とは大きく異なることを世界で初めて明らかにした。
本研究の成果により、色調が悪いという理由で摘出されるかもしれない卵巣が、インドシアニングリーンを用いることで確固とした根拠をもとに温存されうるということである。卵巣は女性ホルモンを生産し、卵子を育む臓器であるため、社会的意義は大きい。