Establishment of chronic endometritis model and analysis of Terocytes involvement

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K18642
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56040:Obstetrics and gynecology-related
• Research Institution: Osaka University
• Principal Investigator: Miyake Tatsuya 大阪大学, 医学系研究科, 助教 (00814766)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: 慢性子宮内膜炎 / 着床 / 生殖医学 / 不妊症 / LPS / テロサイト

Outline of Final Research Achievements

In this study, we generated a new model of chronic endometritis to investigate the effects of endometritis on telocytes in the endometrium and myometrium, induced plasmacytoid cells in the endometrial stroma by intracavitary administration of LPS, and investigated implantation and miscarriage rates. Since we were not able to obtain sufficient results within the time frame of this study, we are still in the process of conducting this study, and the results will be available in the near future.

Free Research Field

生殖医学

Academic Significance and Societal Importance of the Research Achievements

「慢性的な」炎症による病的な状態が女性生殖器におけるテロサイトに与える影響に関する評価は未だ十分になされていない。これまでに慢性子宮内膜炎症例での子宮に存在するテロサイトの発現を確認した検討はなく、今回我々は子宮内膜炎が子宮に存在するテロサイトに及ぼす影響に関して検討することを目的とする。