2020 Fiscal Year Final Research Report
Estrogen regulates squamous metaplasia in the endometrial cancer
| Project/Area Number |
19K18691
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 56040:Obstetrics and gynecology-related
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| Research Institution | Kanazawa University |
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Principal Investigator |
Terakawa Jumpei 金沢大学, 学際科学実験センター, 助教 (90777731)
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| Project Period (FY) |
2019-04-01 – 2021-03-31
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| Keywords | 子宮体癌 / 扁平上皮化生 / エストロゲン / マウスモデル |
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| Outline of Final Research Achievements |
Squamous metaplasia is found in both endometrial cancer patients and the mouse model which carries PTEN inactivation. We found that squamous metaplasia is developed in estrogen-dependent manner by the investigation of animal models. We further demonstrated that a small number of precursor cells which can differentiate into the stratified epithelium arises under the environment with existence of PTEN inactivated epithelial cells.
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| Free Research Field |
生殖生物学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、子宮内膜においてPTENを欠損した上皮細胞が存在する環境下では本来の分化経路から逸脱した細胞集団が出現するという新しい知見を含んでおり、子宮体癌での微小環境変化を理解する上で重要な学術的意義があると考えられる。また、今後癌患者での病態解明や扁平上皮化生の誘導制御といった治療法開発にも結びつくと考えられる。
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