Role of IL-24 in clear cell carcinoma as endometriosis-related ovarian cancer.

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K18706
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56040:Obstetrics and gynecology-related
• Research Institution: Keio University
• Principal Investigator: Iwasa Naomi 慶應義塾大学, 医学部(信濃町), 助教 (10627152)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 卵巣癌 / 子宮内膜症 / 卵巣明細胞癌

Outline of Final Research Achievements

DLX3 was identified as a gene whose expression was downregulated when clear cell carcinoma tumor content fluid was added to immortalized ovarian surface epithelial cell HOSE culture medium. The expression of IL-24 was markedly upregulated when the cystic content fluid of ovarian endometriosis was added to HOSE, but when DLX3 was knocked down in HOSE, the expression of IL24 was upregulated. Thus, it was possible that reduced expression of DLX3 increased IL-24 expression, but no DLX3 expression was observed in normal ovarian surface epithelium. Therefore, it is unlikely that DLX3 contributes to the carcinogenesis.　Addition of IL-24 to HOSE did not alter IL6 or STAT3, suggesting that IL-24 is unlikely to be involved in carcinogenesis.

Free Research Field

婦人科腫瘍学

Academic Significance and Societal Importance of the Research Achievements

卵巣内膜症の内容液および明細胞癌の内容液を卵巣上層上皮細胞においてIL24の発現を上昇させることを発見した。IL24の発がんへの影響は同定できず、内因性のSTING経路の活性化などをみている可能性が考えられた、