Elucidation of leukocyte infiltration in chronic sinusitis and analysis of its relationship with inflammation

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K18726
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56050:Otorhinolaryngology-related
• Research Institution: University of Fukui
• Principal Investigator: Tsutsumiuchi Toshiki 福井大学, 学術研究院医学系部門, 特別研究員 (60720084)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 好酸球性副鼻腔炎 / 好酸球浸潤 / セレクチン / 末梢リンパ節アドレシン

Outline of Final Research Achievements

It was confirmed that the expression of substances on the vascular endotheliums,　which is expressed when eosinophils infiltrate the tissue in eosinophilic chronic rhinosinusitis, is significantly higher in the nasal polyps. We also analyzed that their expression increases depending on severity of eosinophilic chronic rhinosinusitis. On the other hand, it was also confirmed that there is no difference in their expression depending on the presence or absence of complications that are common in eosinophilic chronic rhinosinusitis.
We created the antibodies that could recognize the vascular endothelial materials involved in the infiltration of tissues by neutrophils, because there were no antibodies , which are primarily involved in non-eosinophil sinusitis. We also investigated the expression of eosinophil-related substances on the vascular endothelium using mice modeled on allergic inflammation.

Free Research Field

アレルギー性炎症

Academic Significance and Societal Importance of the Research Achievements

好酸球性副鼻腔炎は難治性、易再発性を特徴とする副鼻腔炎で、機序の解明も不十分な病態である。それら動態の解明の一助となりうる今回の研究結果が、治療法の確立に役立つ可能性がある。また重症度に合わせてのオーダーメイド的な治療プランの確立も行える可能性がある。
また新たな抗体作成で、非好酸球性副鼻腔炎の炎症機序の部分的な解明に役立つ可能性や新たなマウスモデル作成でヒト検体とは異なるアプローチでの病態解明の一助となる可能性がある。