2022 Fiscal Year Final Research Report
Novel Treatment Guidelines for Eosinophilic Sinusitis - Phenotypic Analysis of Pathological Findings
| Project/Area Number |
19K18748
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 56050:Otorhinolaryngology-related
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| Research Institution | Nippon Medical School |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Keywords | 好酸球性副鼻腔炎 / 局所IgE / 濾胞樹状細胞 |
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| Outline of Final Research Achievements |
There are various phenotypes of eosinophilic sinusitis, and we investigated the possibility of classifying them histologically. In the present study, we found that local IgE was higher in eosinophilic sinusitis than in non-eosinophilic sinusitis. This suggests that local IgE may have some influence on the pathogenesis of eosinophilic sinusitis. However, among patients with eosinophilic sinusitis, some had high local IgE and some had low local IgE. In particular, cases with high levels of lymph follicles and follicular dendritic cells tended to have high levels of local IgE. Eosinophilic sinusitis cases with follicular dendritic cells in the tissue and eosinophilic sinusitis cases without follicular dendritic cells are likely to be infiltrated by eosinophils through different mechanisms.
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| Free Research Field |
鼻副鼻腔
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| Academic Significance and Societal Importance of the Research Achievements |
好酸球性副鼻腔炎は難治性の難病疾患である。治療法に関しては、ステロイド療法や最近では分子標的薬などもあるが、それでも改善が乏しい症例もある。
好酸球性副鼻腔炎には様々なフェノタイプがあり、我々はこれを解明することにより将来的には治療法を開発を目標としている。
本研究では、組織中に濾胞樹状細胞が好酸球性副鼻腔症例と濾胞樹状細胞がない好酸球性副鼻腔症例がある事が分かった。そのため、異なるメカニズムで好酸球が浸潤している可能性が高い。それを基に、今後好酸球性副鼻腔炎における組織学的フェノタイプ別の分子標的治療薬指針を作成が期待できると考える。
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