Investigation of Sleep Apnea Syndrome Treatment with HIF1a Inhibitor

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K18751
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56050:Otorhinolaryngology-related
• Research Institution: Kawasaki Medical School
• Principal Investigator: Saika Taro 川崎医科大学, 医学部, 講師 (70509299)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 睡眠時無呼吸 / 間欠的低酸素 / サイトカイン / 炎症 / マウスモデル

Outline of Final Research Achievements

Sleep apnea is one of the most serious diseases that have been reported to be associated with increased risk of myocardial infarction and worsening of diabetes mellitus due to hypoxia that occurs during sleep. Although various therapies have been provided, they sometimes fail to improve the condition, and we believe that a treatment that fundamentally reduces the physical damage caused by intermittent hypoxia during sleep is needed. Therefore, we investigated the possibility of using a molecule that has never been considered as a treatment for this disease as a therapy.

Free Research Field

耳鼻咽喉科

Academic Significance and Societal Importance of the Research Achievements

睡眠時無呼吸は気道閉塞を解除することでその病態を改善することを治療としてきた。しかし、解剖学的に改善困難な場合は睡眠時の低酸素が残存してしまい、炎症性サイトカイン産生などによる身体的負荷を回避しきれない。そのため、低酸素自体で生じる病態に対する治療を考える必要がある。