2021 Fiscal Year Final Research Report
Research related to the early detection of preperimetric glaucoma using optical coherence tomography
Project/Area Number |
19K18840
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 56060:Ophthalmology-related
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Research Institution | Kanazawa University |
Principal Investigator |
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Project Period (FY) |
2019-04-01 – 2022-03-31
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Keywords | 前視野緑内障 / 光干渉断層計 / 上下非対称性 |
Outline of Final Research Achievements |
Because glaucoma is common disease which cause blindness at late stage, the early detection is very important. However, a lack of symptoms in early stage can delay having a medical examination. Also, early glaucoma may be missed during conventional qualitative diagnosis by fundus photograph. We devised useful indicators to detect preperimetric glaucoma focusing on ‘asymmetry’ which is one of features of glaucoma pathology using optical coherence tomography, and published a paper about it after domestic and oversea academic conferences presentations. As a new development, we did a presentation on domestical academic conference about increasing detective ability of early glaucoma even further to use different indices depending on situation where glaucoma finding express on fundus. We are pushing the work forward to publish a paper.
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Free Research Field |
眼科学
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Academic Significance and Societal Importance of the Research Achievements |
緑内障では、欠損した視野を回復させる方法は存在せず、進行を遅らせることが治療の目的である。そのため早期発見が極めて重要であるが、初期~中期では自覚症状がほとんどないうえ、眼底写真での定性的評価では判定医によって判断がばらつくうえ、極早期例での検出能が高くなかった。今回考案した、光干渉断層計による定量的判定の検出能は、緑内障前段階(前視野緑内障)においても極めて高い。発表論文などによって眼科医の認知が近年高まっており、今後検診などのスクリーニングにおいても活用が期待される。
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