Polypoidal choroidal vasculopathy induced by elastic fiber-deficient mice and laser

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K18861
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56060:Ophthalmology-related
• Research Institution: Kansai Medical University
• Principal Investigator: MORI Hidetsugu 関西医科大学, 医学部, 講師 (50802948)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 弾性線維 / 脈絡膜新生血管 / fibrillin-1 / LTBP-2 / LTBP-4

Outline of Final Research Achievements

There were no significant difference about the formation, progression, and speed of choroidal neovascularization (CNV), progression with regards to wild and LTBP-4 gene knocked out (KO) mice. However, less power of retinal photocoagulation led to the formation of CNV in LTBP-4 KO mice compared to wild mice because LTBP-4 KO mice had the weakness of elastic fiber in Bruch's membrane.

Free Research Field

眼科

Academic Significance and Societal Importance of the Research Achievements

弾性線維の脆弱性が脈絡膜新生血管をより生じやすいことがわかった。弾性線維形成にはさまざまなタンパク質が関与し、中でもLTBP-4ノックアウトマウスでより脈絡膜新生血管をより生じやすいことから、既存の抗VEGF薬に新たな成分、弾性線維脆弱化促進する蛋白をブロックすることで、脈絡膜新生血管の発生・活動性を減弱させる可能性がある。