Symptoms of dry eyes and synaptic dysfunction in the medulla and the cervical cord

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K18895
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56060:Ophthalmology-related
• Research Institution: Kanazawa Medical University
• Principal Investigator: NAKANO Katsuya 金沢医科大学, 医学部, 研究員 (50835527)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: ドライアイ / 三叉神経脊髄路核 / GFAP

Outline of Final Research Achievements

Dry eye is chronic ocular disease showing many symptoms like ocular dryness sensation, pain, fatigue and visual disturbance. A part of the symptoms in some patients are recently reported to involve the dysfunction of central nervous system. In present study, we showed that chronic ocular dryness changes expression of glial markers and inflammatory molecules in mouse spinal trigeminal nucleus.

Free Research Field

神経科学

Academic Significance and Societal Importance of the Research Achievements

ドライアイにおける自覚症状の異常を引き起こすメカニズムのひとつとして、三叉神経脊髄路核の炎症による異常が関与している可能性を示すことができた。