2021 Fiscal Year Final Research Report
Analysis of chymase in orbital tissue of thyroid eye disease
Project/Area Number |
19K18896
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 56060:Ophthalmology-related
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Research Institution | Osaka Medical and Pharmaceutical University |
Principal Investigator |
Mimura Masashi 大阪医科薬科大学, 医学部, 非常勤講師 (90733436)
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Project Period (FY) |
2019-04-01 – 2022-03-31
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Keywords | 甲状腺眼症 / chymase / 眼窩線維芽細胞 |
Outline of Final Research Achievements |
We researched chymase activity in thyroid eye disease (TED) using an animal model and human orbital soft tissue . Regarding the animal study, we tried to develop a TED mouse model; however, the model was found not to observe apparent orbital inflammation despite high thyroid hormone in the blood, so we could not conduct further investigation. Regarding the study using human tissue, we have collected discarding orbital tissue during the surgeries for both TED and non-TED patients. The analysis revealed no difference in chymase activity between TED and the control group.
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Free Research Field |
眼科
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Academic Significance and Societal Importance of the Research Achievements |
今回の研究成果からは、残念ながらchymaseを介して甲状腺眼症に対する新たな分子標的療法を開発するきっかけを見出すことはできなかった。しかし、本研究を通じて、甲状腺眼症の動物モデルの作成について、今後さらに造形を深めるきっかけとなり、研究発展の足場をつくることができた。また、ヒト軟部組織を用いた研究については、さらなるデータの蓄積により、新たな知見を見出す可能性があり、総じて有意義な研究であった。
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