Analysis of Hypoxic Stress Response in Animal Models of Melanoma Metastasis

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K18903
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56070:Plastic and reconstructive surgery-related
• Research Institution: Hokkaido University
• Principal Investigator: KUSAJIMA Erika 北海道大学, 大学病院, 医員 (30813547)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: HIF-1α / メラノーマ / 低酸素応答 / リンパ管機能不全

Outline of Final Research Achievements

Cancer is said to utilize the body's own hypoxic response system to promote growth, invasion, and metastasis. Therefore, the hypoxic response has been attracting attention as a target for cancer therapy. In this study, melanoma was transplanted into a mouse hindlimb lymphatic dysfunction model, and the effect of administration of YC-1, a HIF-1α inhibitor, on axillary lymph node and lung metastatic volume was examined. Although the inhibitory effects of YC-1 on melanoma metastasis has been previously reported, in this study, we did not find any inhibitory effect of YC-1 on metastasis.

Free Research Field

形成外科

Academic Significance and Societal Importance of the Research Achievements

がん組織において増殖・浸潤・転移を促進させる低酸素応答システムを抑制することができれば、腫瘍特異的な標的療法となりうる。本研究はマウスモデルを用いて、HIF-1αの活性を調整する薬剤投与により、通常のマウスおよび転移能が亢進しているとされるリンパ管機能不全マウスモデルにおいて、転移動態に及ぼす影響の解明を目的とした。