2022 Fiscal Year Final Research Report
Sonodynamic therapy of soft tissue sarcoma with ultrasound using 5-Aminolevulinic acid (5-ALA)
Project/Area Number |
19K18909
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 56070:Plastic and reconstructive surgery-related
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Research Institution | Kyoto Prefectural University of Medicine |
Principal Investigator |
Kawarazaki Ayako (岡田彩子) 京都府立医科大学, 医学(系)研究科(研究院), 講師 (50550498)
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Project Period (FY) |
2019-04-01 – 2023-03-31
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Keywords | 軟部悪性腫瘍 / 超音波力学療法 / 5-ALA |
Outline of Final Research Achievements |
5-Aminolevulinic acid (5-ALA) is metabolized into protoporphyrin IX (Pp IX). Protoporphyrin Ⅸ excessively accumulate in proliferating cancer cells, could cause destruction of the cancer cells by irradiation of light exposure. The photodynamic therapy (PDT) is a fascinating therapy. Moreover, 5-ALA takes on a role of a sonosensitizer, could be irradiated by ultrasound. The sonodynamic therapy (SDT) has the possibility of the effect of the induction cell killing as well as PDT, or more safety than PDT. In this research, we used the SW872 cell and the HT1080 cell. We tested the effect by the combination of 5-ALA and ultrasound.
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Free Research Field |
創傷、腫瘍
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Academic Significance and Societal Importance of the Research Achievements |
軟部悪性腫瘍は希少癌であり、多数の組織型から成る腫瘍であるため、治療の確立が難しいとされている。近年承認されている分子標的治療薬は組織型により効果は様々である。一方、今回の研究テーマである超音波力学療法による軟部悪性腫瘍に対する効果についての報告は見当たらず、今後治療となる可能性を検討することを目的とした。
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