2020 Fiscal Year Final Research Report

Study to clear the mechanism of propranolol for infantile hemangioma

Research Project

Project/Area Number	19K18913
Research Category	Grant-in-Aid for Early-Career Scientists
Allocation Type	Multi-year Fund
Review Section	Basic Section 56070:Plastic and reconstructive surgery-related
Research Institution	Jichi Medical University (2020) Saitama Children's Medical Center (2019)
Principal Investigator	Fujiki Masahide 自治医科大学, 医学部, 講師 (50532066)
Project Period (FY)	2019-04-01 – 2021-03-31
Keywords	乳児血管腫 / プロプラノロール
Outline of Final Research Achievements	The vascular endothelial cells isolated from infantile hemangioma were cultured. Although the propranolol were added to culture solution, proliferation of endothelial cells was not inhibited.
Free Research Field	形成外科学
Academic Significance and Societal Importance of the Research Achievements	プロプラノロールの乳児血管腫の退縮作用は、血管内皮細胞の増殖抑制とは異なる機序によって引き起こされていることが示唆された。