Development of a novel treatment for syndromic craniosynostosis using disease-specific induced pluripotent stem cells

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K18930
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56070:Plastic and reconstructive surgery-related
• Research Institution: Jichi Medical University
• Principal Investigator: Chi Daekwan 自治医科大学, 医学部, 非常勤講師 (50784344)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: 頭蓋骨縫合早期癒合症

Outline of Final Research Achievements

We established disease-specific induced pluripotent stem cell lines from the patients of syndromic craniosynostosis and conducted experiments to induce bone and cartilage differentiation.
However, we were not able to identify the phenotypes in bone and cartilage differentiation of disease-specific iPS cells within the study period.

Free Research Field

形成外科学

Academic Significance and Societal Importance of the Research Achievements

未だに根本的な治療法がない症候群性頭蓋骨縫合早期癒合症に対して新しいアプローチで解決を試みた。疾患特異的iPS細胞の骨・軟骨分化の過程における異常について分子生物学的解析を行うことにより、新規治療法開発の糸口が見つかると考えたが、期間内の研究では形質の違いを同定することはできなかった。骨・軟骨分化の方法に問題がある可能性があり、今後も継続していきたい。