2023 Fiscal Year Final Research Report
Exploring the relationship between metabolic activity and environmental factors in oral cancer cells using real-time monitoring system.
| Project/Area Number |
19K18957
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 57020:Oral pathobiological science-related
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2024-03-31
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| Keywords | 口腔がん / メタボローム / がんの代謝活動 / 環境pH / 栄養条件 |
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| Outline of Final Research Achievements |
The objective of this project was to investigate the effects of various environmental factors and drugs such as anticancer agents on the metabolic activity of human oral squamous cell carcinoma cells (HSC-2) by using a real-time monitoring system for cell metabolism. As a result, it was found that both proliferation and glucose metabolism of HSC-2 cells increased under high glucose concentration, and their sensitivity to 2DG was decreased.
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| Free Research Field |
口腔がん
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| Academic Significance and Societal Importance of the Research Achievements |
ヒト口腔扁平上皮癌細胞(HSC-2)の増殖や糖代謝、及び2-deoxy glucose（以下2DG）感受性に対する培養時の栄養基質濃度の影響について検討した結果、本細胞は高グルコース濃度下で増殖能、糖代謝能が共に高くなり、２DGへの薬剤感受性が低下することが判明した。したがって抗がん剤使用時に糖尿病などの基礎疾患の存在下では薬剤の効果が薄れる可能性が示唆された。
本研究からがんの臨床治療における血中糖濃度の管理の重要性が示唆され、今後は効果的な抗がん剤の使用方法の確立の一助となる可能性を秘めているものと考えられた。
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