Effect of periodontal infection on cardiac hypertrophy through dysregulation of autophagy and its mechanism.

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K18985
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57030:Conservative dentistry-related
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Shiheido Yuka 東京医科歯科大学, 大学院医歯学総合研究科, 非常勤講師 (60791853)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 歯周病原細菌 / オートファジー

Outline of Final Research Achievements

An association between periodontal disease and cardiovascular disease has been suggested, but the detailed mechanism remains unclear. Recently, dysregulation of autophagy, an intracellular degradation mechanism, has been reported to be involved in several systemic diseases. In particular, autophagy has been shown to play an important role in maintaining the homeostasis of cardiomyocytes, which are non-dividing cells. Based on the results of previous studies, the applicant has been investigating the possibility that dysregulation of autophagy may hold the key to elucidating the relationship between periodontal disease and cardiovascular disease.
This year, we were able to synthesize the results of in vivo and in vitro studies obtained to date.

Free Research Field

歯周病学

Academic Significance and Societal Importance of the Research Achievements

本研究よりオートファジー制御機構が歯周病と心血管疾患とを結びつける因子である可能性を一層高めることができた。さらなる研究を進めることで世界に先駆けてオートファジー制御機構をターゲットとした新規治療法の確立や創薬開発へと発展させることができると考える。