Establishment of safe and efficient bone regeneration with scaffold materials and growth factors in diabetic condition

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K19007
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57030:Conservative dentistry-related
• Research Institution: Tokyo Dental College
• Principal Investigator: BIzenjima Takahiro 東京歯科大学, 歯学部, 講師 (40755021)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 歯周組織再生療法 / 糖尿病 / FGF-2 / DBBM

Outline of Final Research Achievements

The purpose of this study was to investigate the effects of the combined use of fibroblast growth factor (FGF)-2 with deproteinized bovine bone mineral (DBBM) on the healing of experimental periodontal defects in type 2 diabetes rats. Periodontal defects were surgically created at maxillary first molars. Then, defects were assigned to two subgroups: treatment with FGF-2 alone and FGF-2 with DBBM, following a split mouth design. In diabetes groups, FGF-2 with DBBM treatment increased new bone formation and suppressed epithelial down-growth. Within the limitation of the present study, it was concluded that FGF-2 with DBBM treatment effectively promoted healing surgical periodontal defect in type 2 diabetic rats.

Free Research Field

医歯薬学

Academic Significance and Societal Importance of the Research Achievements

本研究では糖尿病状態の実験動物に対して，歯周組織再生療法を行い治癒に関する影響を比較・検討した。歯槽骨吸収を模した状態を，実験動物の歯周組織に作成し再生療法を行った。再生療法に関しては，成長因子であるFGF-2と足場となるDBBMを併用した歯周組織再生療法を行った。今回の結果では，糖尿病状態の実験動物においても，成長因子と足場材料を組み合わせた歯周組織再生療法を行うことで，歯槽骨再生に改善が認められた。本研究で得られた知見を基とし，さらに効率的な歯周組織再生療法や骨造成法が確立されれば，糖尿病をはじめ，全身状態に問題がある患者への歯周治療やインプラント治療の飛躍的な発展につながると思われる。