Establishment of tooth-gingival adhesion method using adhesion protein and collagen self-assembly peptide

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K19040
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57030:Conservative dentistry-related
• Research Institution: The Nippon Dental University
• Principal Investigator: Maeno Masahiko 日本歯科大学, 生命歯学部, 講師 (20736334)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 接着タンパク質 / コラーゲン自己生成ペプチド / 歯ー歯肉間接着 / 光機能化 / シーリング法

Outline of Final Research Achievements

Loss of hard tissue-soft tissue adhesion is a major challenge in maintaining a healthy natural dentition. In this study, we aimed to establish a method for generating bio-adhesion between hard and soft tissue. A method utilizing collagen self-generating peptides was investigated, but the amount and extent of fixation were insufficient to achieve adhesion between hard and soft tissues, so modification of the adherend surface through photofunctionalization was examined. Although a certain effect of photofunctionalization was observed for various restorative materials, the effect on tooth structure was found to be insufficient. Therefore, a sealing method targeting the tooth surface was investigated and useful findings were obtained. However, there are still issues to be addressed in order to obtain useful effects on soft tissues.

Free Research Field

保存治療系歯学

Academic Significance and Societal Importance of the Research Achievements

硬組織－軟組織間の結合喪失は、その治癒の困難さから細菌の再侵入を許しやすく、最終的には支持組織の喪失によって歯の抜去に至るため、健全な天然歯列維持の大きな課題であり、これを解決することは健全な歯列・咬合の維持に大きく貢献する。本研究の過程から、光機能化による一定の効果を推察されたものの、歯質および軟組織に対する応用実現には課題が残った。一方で、並行して行った研究から、硬組織と対象としたシーリング法において歯と修復物の強固な一体化を通じ、象牙質歯髄複合体を保護する有用な手法が見いだされた。硬組織の損傷拡大は最終的に硬組織－軟組織間の結合喪失を意味するため、予防的な観点で意義ある成果と考えられる。