2023 Fiscal Year Final Research Report
Development of multifunctional EDTA-based root canal irrigant for refractory biofilm infections
| Project/Area Number |
19K19041
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 57030:Conservative dentistry-related
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| Research Institution | Kanagawa Dental College |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2024-03-31
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| Keywords | EDTA / アルカリ性 / 根管洗浄剤 / 抗菌効果 |
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| Outline of Final Research Achievements |
Fundamentals of the antibacterial effect of a highly functional EDTA solution adjusted to a strongly alkaline region, the organic matter dissolving effect by measuring the biofilm removal effect, and the inorganic dissolving effect due to the dentin smear layer removal effect and dentin demineralization ability. A research report of a research evaluation showed that it has antibacterial activity, biofilm removal effect, and excellent smear layer removal effect, and is also a chemically stable and excellent root canal cleaning agent, and has an organic and inorganic dissolving effect. It was shown to be a root canal cleansing agent with excellent chemical stability that can be used alone.
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| Free Research Field |
歯内療法学
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| Academic Significance and Societal Importance of the Research Achievements |
中性領域でのEDTA溶液単独では抗菌作用，有機質溶解作用を持ち合わせておらず，加えてNaClO溶液とEDTA溶液の併用時にEDTAが有するキレート作用の阻害効果が報告されており有機質と無機質の両方が除去可能な一本化した根管洗浄液が存在していなかった．しかしながらpHを強アルカリ性領域に調整することでEDTA溶液は細菌細胞壁を破壊し，細菌増殖を抑制し抗菌作用を有すること，ハイドロキシアパタイトに結合した有機質成分を溶解することが確認されたことで，EDTAを強アルカリ性領域に調整した，新規多機能性根管洗浄液の開発は臨床応用への可能性が非常に高い研究であると考える．
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