2021 Fiscal Year Final Research Report
A Study of Organogermanium for the Prevention of Oral Mucositis
| Project/Area Number |
19K19052
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 57040:Regenerative dentistry and dental engineering-related
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 有機ゲルマニウム / 口腔粘膜炎 / 活性酸素種 / 抗炎症作用 / 歯学 |
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| Outline of Final Research Achievements |
The purpose of this study was to investigate whether the antioxidant organic germanium (bis-β-carboxyethylgermanium sesquioxide: Ge-132) has a preventive effect on oral mucositis, and to examine its anti-inflammatory and healing-promoting effects.
The results indicated that Ge-132 had an anti-inflammatory effect when applied topically to oral mucositis, but there were no differences in the effects of Ge-132 across a concentration gradient or in its ability to promote healing.
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| Free Research Field |
予防歯科学分野
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| Academic Significance and Societal Importance of the Research Achievements |
口腔粘膜炎はひとたび発症すると，増悪の一途をたどり，著しい自発痛や接触痛を伴う．その結果，がん治療患者のQuality of Life（QOL）を低下させる．Ge-132は日本で独自開発された半金属有機化合物である．抗酸化作用に加え，ATP受容体に作用し，疼痛緩和作用があることも知られている．
本研究の成果としては，Ge-132は口腔粘膜に対して抗炎症作用があることが示唆されたため，がん治療においての支持的療法の一助として可能性が見出だされた.
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