Development of new treatment methods on medication related osteonecrosis of the jaw

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K19055
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57040:Regenerative dentistry and dental engineering-related
• Research Institution: Kyushu University
• Principal Investigator: Noriyuki Yasunami 九州大学, 歯学研究院, 助教 (00758021)
• Project Period (FY): 2020-03-01 – 2023-03-31
• Keywords: MRONJ

Outline of Final Research Achievements

Medication-Related Osteo Necrosis of the Jaw (MRONJ) marked by necrosis of bone is a big problem in dental field. However, the causes have not solved yet and there is no treatment for it. We have reported the effects of statins, which are drugs for dyslipidemia, on promoting bone formation and soft tissue healing in the extraction socket. Therefore, we hypothesized that statins promote the healing of MRONJ and verified the healing effect of statins on MRONJ. Using MRONJ-like rats, fluvastatin was administered and evaluated near the site of MRONJ onset. As a result, it was confirmed that the administration of statins in both soft and hard tissues promotes healing.

Free Research Field

歯科補綴

Academic Significance and Societal Importance of the Research Achievements

近年、骨吸収抑制薬や抗RANKL抗体による副作用として顎骨壊死や骨髄炎に似た骨露出が報告されるようになってきた。この薬剤関連顎骨壊死(MRONJ)において確立した予防・治療法がないのが現状である。本実験において、MRONJ様ラットにフルバスタチンを単回局所投与することによってMRONJの治癒を促進することを確認した。すなわち、フルバスタチンの局所単回投与はMRONJに対する新規治療法となる可能性が示唆された。難治性であり、治療方法が確立されていないMRONJの新規治療法になる可能性があり、社会的意義があると考える。