Development of the subperiosteal bioreactor technology using temperature-responsive bioabsorbable gel sustained release of PRP

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K19070
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57040:Regenerative dentistry and dental engineering-related
• Research Institution: Nagasaki University
• Principal Investigator: Koga Takamitsu 長崎大学, 医歯薬学総合研究科(歯学系), 客員研究員 (50779428)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 多血小板血漿

Outline of Final Research Achievements

In this study, we developed bone regeneration technique by an easy procedure to inject the bioabsorbable gel which incorporated growth factors under the periosteum with a syringe.
A certain degree of osteoinductivity were confirmed in animal experiment of bioabsorbable gel mixed with freeze-dry platelet-rich plasma. We are conducting detailed analysis about the mechanism of this bone osteoinductivity.
Also, we examined the safety of freeze-dried platelet-rich plasma in a human body as a pilot study in clinical research. The results obtained in this study suggested that FD-PRP can be used safely for bone engineering in clinical practice. We published an article in Journal of Clinical Medicine and presented in the conference.

Free Research Field

外科系歯学

Academic Significance and Societal Importance of the Research Achievements

本研究では、生体吸収性ゲルに成長因子を添加し局所応用することで、骨誘導が行える可能性が示唆され、低侵襲な骨再生治療の先駆け的研究に位置付けられる。今回は歯槽骨再生を主眼に研究を進めたが、本技術は骨膜下であればいずれの部位でも応用可能であり、整形外科分野などへの応用も期待できる。
また骨再生治療が必要となる場合の多くは高齢者であり、全身状態に問題がある場合は侵襲度の高い治療は避けざるを得ないのが現状である。しかし本技術のように治療の低侵襲化を進めることで適応症は拡大し、ひいては国民の健康増進に寄与すると考えられる。