Fabrication of aesthetic antibacterial silver-calcium phosphate root base materials

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K19081
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57040:Regenerative dentistry and dental engineering-related
• Research Institution: National Institute of Advanced Industrial Science and Technology
• Principal Investigator: Sugiura Yuki 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究員 (70755040)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 骨補填材 / 銀 / 抗菌性 / バイセラミックス

Outline of Final Research Achievements

Since the introduction of biomaterials, infection has been a serious problem in clinical operations. Ag-substituted octacalcium phosphate (OCP) blocks exhibiting contact antibacterial ability were fabricated from precursor dicalcium dihydrate anhydrate blocks via immersion in both Ag+- and Na+ containing ammonium phosphate weak basic buffer solutions. Although the Ag contents of the Ag-substituted OCP blocks (0.17 ± 0.01 at%) were much lower than those of Ag-substituted OCP powders (1.72 ± 0.18 at%) prepared using Ag solutions with the same Ag concentration (20 mmol/L), the Ag-substituted OCP blocks exhibited excellent contact antibacterial activities toward various
pathogens. In vivo implanting in bone defects evaluations indicated that the biocompatibility of the Ag-substituted OCP blocks was excellent and similar to that of the OCP blocks without Ag.

Free Research Field

バイオマテリアル

Academic Significance and Societal Importance of the Research Achievements

本研究では、抗菌材としてAgを用いるにもかかわらず、変色しないリン酸カルシウム材料の創製を最終目的とし、研究を行った。歯科・整形外科において、骨再建・再生時の術後感染は深刻なリスクである。特に、骨補填材由来の感染は、深刻化しやすい。抗菌元素であるAgを骨補填材に強固に含有させることで、術後感染を予防し、かつ高い骨再生能を発揮する材料の開発を目指したものである。