2022 Fiscal Year Final Research Report
Elucidation of the pathogenesis of Alzheimer's disease induced by occlusal disharmony.
| Project/Area Number |
19K19113
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 57050:Prosthodontics-related
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Keywords | 歯学 / 認知症 / アルツハイマー |
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| Outline of Final Research Achievements |
We hypothesized that hyperocclusion decreases cognition via Alzheimer's disease-associated molecule expression in the brain. The present study is aimed to elucidate the relationships among occlusal disharmony, cytokine and cognitive-regulated molecule expression in the brain, and the impairment of learning and memory cognition. The expression levels of amyloid-β and phosphorylated tau were significantly upregulated 1 week after hyperocclusal loading in the hippocampus of 2-month-old mice but were constant in 12-month-old mice. Occlusal disharmony-induced interleukin-1β expression may contribute to accumulation of cognitive suppressor molecules such as amyloid-β and phosphorylated tau and activate their clearance proteins, resulting in protection against transient dementia in young but not older individuals.
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| Free Research Field |
歯学
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| Academic Significance and Societal Importance of the Research Achievements |
アルツハイマー型認知症は、代表的な認知機能低下を誘発する疾患としてしられており、近年になってようやく治療薬が認可されつつあるが、いまだに十分な薬効は証明されていない。よって、その発症や進行の予防方法の究明が重要となる。アルツハイマー型認知症の発症と相関関係を示す疾患はいくつか報告されているが、歯科領域では歯周病がもっとも研究報告が多く、歯周病治療が一定の効果があることは証明されている。しかしながら、口腔機能としては同等に重要とされる咬合との因果関係を示す報告は乏しいため、有意義な実験データが得られれば重要な知見となることが期待できる。
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