Therapeutic interactions between mesenchymal stem cells for healing and preventing medication-related osteonecrosis of the jaw.

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K19133
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57050:Prosthodontics-related
• Research Institution: Kyushu University
• Principal Investigator: Yuri Matsuura (松浦) 九州大学, 歯学研究院, 特別研究員 (80778837)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: 間葉系幹細胞 / 薬剤関連顎骨壊死 / ミトコンドリア / 細胞治療

Outline of Final Research Achievements

Mesenchymal stem cells (MSCs) have been isolated from a variety of tissues including bone marrow, adipose, and mucosa. MSCs have the capacities for self-renewal and differentiation. Some reports have been published on systemic administration of MSCs leading to functional improvements by engraftment and differentiation, thus providing a new strategy to regenerate damaged tissues. Recently, it has become clear that MSCs possess immunomodulatory properties and can treat diseases. However, it is difficult to demonstrate extensive engraftment of cells and there are no convincing clinical results. Here, we investigated the effect of aspirin for MSC treatment by using medication-related osteonecrosis of the jaw (MRONJ)-like mice model.These data suggest that donor MSCs recognize the state of host MSCs, and the aspirin treatment may contribute to the therapeutic effects of MSCs.

Free Research Field

インプラント・義歯補綴学分野

Academic Significance and Societal Importance of the Research Achievements

間葉系幹細胞（mesenchymal stem cell: MSC）は優れた増殖能、分化能、細胞制御能を有しており、組織、臓器における再生治療や様々な疾患に対する細胞治療のディバイスとして大きな可能性を有している。本解析を通して、MRONJに対するMSCの治療効果はMSCを採取された個体の全身状態に影響を受けること、さらにMSC同士の直接的な相互作用が影響する可能性が示唆された。