Fluorinated hydroxyapatite coatings synthesized by pulsed laser deposition On NANOZR-substrate: Surface characterization, cell activity and osteogenesis ability

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K19146
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57050:Prosthodontics-related
• Research Institution: Osaka Dental University
• Principal Investigator: Naito Daisuke 大阪歯科大学, 歯学部, 講師(非常勤) (80758087)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: インプラント / in vitro / in vivo / ハイドロキシアパタイト

Outline of Final Research Achievements

The purpose of this study was to evaluate the surface characterization, mechanical properties, bioactivity in vitro and in vivo of NANOZR-substrate FHAp coatings obtained by pulsed laser deposition (PLD). Surface morphology, crystalline phase identification, identification of functional groups , bond strength testing and cell morphology, cell proliferation, evaluation of hard tissue Differentiation and the amount of new bone formation of materials were measured. These results suggest that the NANOZR-substrate FHAp coatings is the good candidate for increasing the osseointegration of the implant in contact with the bone and can be most promising for implant fabrication compared to the unmodified NANOZR.

Free Research Field

再生歯学

Academic Significance and Societal Importance of the Research Achievements

本研究の学術的な特色は，ナノテクノロジーの一つである材料表面のナノ構造制御に着目し，新たな生体材料を開発し他分野への応用を視野に入れているという点にある．オッセオインテグレーションとともにバイオインテグレーションが注目される中，アパタイトシートならびに細胞シートを応用させたこの結果は医科界・歯科界において多くの患者に普及させることが期待できる．