Challenge to vertical bone augmentation and bone regeneration medicine using beta-tricalcium phosphate granular cement

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K19163
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57060:Surgical dentistry-related
• Research Institution: The University of Tokushima
• Principal Investigator: FUKUDA Naoyuki 徳島大学, 大学院医歯薬学研究部(歯学域), 助教 (10804156)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: β型リン酸三カルシウム / 自己硬化性 / 顆粒セメント / 垂直的骨造成 / 骨再生 / 骨再建

Outline of Final Research Achievements

Vertical bone augmentation using self-setting beta-tricalcium phosphate granular cement (β-TCPGC) was examined in rabbit calvarial bone. Morphological and histological analyses were conducted at 2, 4, and 16 weeks after surgery. In all periods, β-TCPGC maintained its created form without migration or flowing out. In histological results, β-TCPGC group showed good tissue response as well as control group. From 2 to 4 weeks after surgery, few amount of cells and blood vessels penetrated into the β-TCP GC, and limited osteoconductivity surrounding the β-TCP GC was observed. However, the amount of new bone in the β-TCP GC was comparable to the control group at 16 weeks after surgery.

Free Research Field

外科系歯学

Academic Significance and Societal Importance of the Research Achievements

本研究成果から、β-TCPGCはその自己硬化性からメンブレンやチタンメッシュなどによる被覆を必要とせずにそれ自体が形状を維持しながら充填部に保持されることで、将来的に本材単独での垂直的骨造成を可能とする新たな骨再建および骨再生用のデバイスになる可能性が示唆された。