Oral microbiome in osteoradionecrosis after carbon-ion radiotherapy for head and neck cancer

2023 Fiscal Year Final Research Report

• Project/Area Number: 19K19183
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57060:Surgical dentistry-related
• Research Institution: National Institutes for Quantum Science and Technology
• Principal Investigator: Ikawa Hiroaki 国立研究開発法人量子科学技術研究開発機構, QST病院 治療診断部, 医長 (00793928)
• Project Period (FY): 2019-04-01 – 2024-03-31
• Keywords: 口腔癌 / 重粒子線治療

Outline of Final Research Achievements

Osteoradionecrosis is a late complication after carbon-ion radiation therapy (CIRT) for head-and-neck cancer, and bacterial infection could be a serious clinical problem. Therefore, this study aimed to elucidate the characteristics of the microbiome in osteoradionecrosis after CIRT for head-and-neck cancer using next-generation sequencing.
The results of this study, osteoradionecrosis after CIRT for head-and-neck cancer had different microbiomes from other sites in the oral cavity, with gram-negative bacilli being particularly numerous.

Free Research Field

口腔癌

Academic Significance and Societal Importance of the Research Achievements

放射線性骨髄炎発症部位の細菌叢を解明することで、より効果的な顎骨壊死の発現予防と感染制御の戦略を確立することが可能となると思われる。