Analysis of Difficult Airway Management Using Working Heart-Brainstem Preparation

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K19209
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57060:Surgical dentistry-related
• Research Institution: Showa University
• Principal Investigator: Tachikawa Satoshi 昭和大学, 歯学部, 助教 (60781036)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: CVCI / 全身麻酔 / 経動脈灌流標本 / Phox2b

Outline of Final Research Achievements

In this research, we are studying a transcription factor called Phox2b, which is involved in the development of the autonomic nervous system, such as respiration. Through repeated research, we have now discovered that this transcription factor Phox2b may be involved not only in respiration but also in mastication and saliva secretion in the field of dentistry. Conference presentations (Physiological analysis of small reticular neurons expressing the transcription factor Phox2b, 2019, 13th Meeting on Sensory-Motor Integration Mechanisms in the Trigeminal Nerve Region and Electrophysiological and Morphological Analysis of Phox2-positive Neurons in the Small Reticular System, 2020, 62nd (The 62nd Annual Meeting of the Japanese Society of Basic Dental Medicine). We are currently writing a paper for submission, which will be published within this year.

Free Research Field

歯科麻酔

Academic Significance and Societal Importance of the Research Achievements

この研究で、呼吸などの自律神経系の発生に関与するPhox2bといわれる転写因子の持つ役割が、呼吸のみならず、歯科の分野である咀嚼や唾液分泌に関与している可能性を見出すことができた。近年、唾液の分泌のメカニズムはおおよそわかっているが、新たな唾液分泌のメカニズム解明や、呼吸中枢に関する疾患の遺伝的解析に重要な役割をもたらす知見が得られた。この成果に関しては学会発表も行っている。