2022 Fiscal Year Final Research Report
Verification of the safety of intravenous sedation for attention-deficit/hyperactivity disorder and development of a new systemic management method
| Project/Area Number |
19K19215
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 57060:Surgical dentistry-related
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| Research Institution | Tsurumi University |
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Principal Investigator |
Yamada Makiko 鶴見大学, 歯学部, 非常勤講師 (20556526)
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Keywords | microdialysis / ADHD / stress handling |
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| Outline of Final Research Achievements |
Handing stress enhanced monoaminergic activity in the locus coeruleus and the prefrontal cortex, dorsal raphe nucleus and amygdala. Local infusion of midazolam and NBI127914 inhibited the enhanced of these neural activity under stress conditions, whereas dexmedetomidine did not inhibit the enhanced.
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| Free Research Field |
静脈内鎮静法
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| Academic Significance and Societal Importance of the Research Achievements |
歯科治療はストレスを引き起こすストレッサーとなりうる ．歯科麻酔臨床では，ストレス軽減に静脈内鎮静法が有効である．しかしながら，現在静脈内鎮静法を行う機会が増えているが，脳内複数部位のモノアミン神経系活動の中枢神経系作用発現機構の検討はほとんど行われていない．
本研究では、静脈内鎮静法薬の中枢神経作用機構を明らかすることで歯科医療の安全性の向上を図ることができる.
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