Evaluation of the additive manufacture porus titanium having newly bone formation

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K19216
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57060:Surgical dentistry-related
• Research Institution: Osaka Medical and Pharmaceutical University
• Principal Investigator: Inoue Kazuya 大阪医科薬科大学, 医学部, 講師 (00761503)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: チタン / 表面処理 / ポーラス構造 / 骨結合能

Outline of Final Research Achievements

we were able to obtain knowledge on the bonding pattern between titanium and bone. Titanium specimens were implanted in rat calvarial bone , and mechanical tests, histological evaluation using non-decalcified polished specimens, and surface analysis using a scanning electron microscope were conducted. It was found that the titanium specimens made by 3D laminated modeling technique had a porous structure, improved hydrophilicity, and early bone-bonding ability by heat treatment with mixed acids. Two papers were published in overseas journals, one review article in a domestic academic conference, one presentation in an international conference, and six presentations in domestic academic conferences within the research institute.

Free Research Field

インプラント

Academic Significance and Societal Importance of the Research Achievements

本研究では歯科インプラントや骨の再建の際に用いられているチタンに関する研究です。骨とチタンがより強固に結合することで、歯科インプラントや再建プレートの緩みや感染などが起こりにくくなることを目的に研究を進めました。結果的に三次元積層造形技術を用いたチタンは特殊な処理を施すことで、表面にマイクロ・ナノスケールの凹凸が出来ることで、周囲の骨からの細胞誘導・分化を促進することが明らかとなりました。本技術を既存の歯科インプラントや再建プレートに応用することが出来れば、医療技術の発展に貢献できると考えています。