2024 Fiscal Year Final Research Report
Association Analysis of Genetic Polymorphisms in Pain Receptors with the Phenotypes of Cancer Pain: Toward the Development of Novel Diagnostic and Therapeutic Approaches
| Project/Area Number |
19K19218
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 57060:Surgical dentistry-related
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2025-03-31
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| Keywords | 口腔がん / SNPs / 痛み |
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| Outline of Final Research Achievements |
This study included 24 patients histopathologically diagnosed with oral cancer who provided informed consent after visiting the Department of Oral and Maxillofacial Surgery at Fukuoka Dental College Medical and Dental Hospital.At the initial consultation, pain was more frequently reported in cases of gingival and tongue cancer. Larger tumor size (T classification) tended to be associated with greater pain intensity. Histopathological analysis revealed a significant association between vascular invasion and increased pain. Although not statistically significant, patients with a YamamotoーKohama (YK) grade of 3 or higher were more likely to report pain.
Malignant progression in oral cancer varies by pathology, tumor location, age, and lifestyle. Future studies aim to identify clinical and genetic markers to better understand the mechanisms of malignancy and cancer-related pain.
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| Free Research Field |
口腔がん
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| Academic Significance and Societal Importance of the Research Achievements |
アルコール摂取により紅潮するフラッシャー、辛いものが苦手な人が口腔がんリスクとなる可能性を検討した。歯科検診で用いる検診票で遺伝子多型を推測し、口腔がん発症リスクの高い患者を抽出できる可能性がある。それらの患者には 専門医の受診を促すことで、口腔がん検診の受診率向上により早期発見を目指す。今後症例数を増やして治療方策に反映する検査項目を見出していく予定である。
また、簡便で安価なスクリーニングであれば、口腔がん患者が多いにもかかわらず、検診が受けられない、南アジアの国々において、早期発見ができるようになる可能性がある。そのような方策を検討していきたい。
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