Stage specific effect of inhibiting cell proliferation on tooth morphogenesis

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K19264
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57070:Developmental dentistry-related
• Research Institution: Osaka University
• Principal Investigator: Isogai Yukako 大阪大学, 歯学研究科, 招へい教員 (20724743)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: 歯牙発生 / 細胞増殖 / 形態形成

Outline of Final Research Achievements

This year, we analyzed how various cell proliferation modifiers affect tooth development using mice suitable for research on tooth development. As a result, it was found that specific tooth hypoplasia is caused not only in the sample treated with chemotherapy having an inhibitory effect on cell proliferation but also in the activation and inactivation of the retinoic acid signal pathway essential for maxillofacial formation.

Free Research Field

矯正歯科

Academic Significance and Societal Importance of the Research Achievements

今回の研究成果では、細胞増殖抑制効果のある化学療法を行った場合の歯牙形成不全には他の遺伝的、環境的要因も影響を及ぼす可能性が高い事を示唆しており今後の研究においては歯牙発生時において組織が受けている様々な外的内的要因の探求とそれらの相互作用の解明が必要である事を示すものである。