Cell dynamics analysis of palate tissue in a cleft palate mouse model using live imaging technology

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K19291
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57070:Developmental dentistry-related
• Research Institution: Osaka University
• Principal Investigator: Aoyama Gozo 大阪大学, 歯学部附属病院, 医員 (00838542)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: 口唇口蓋裂 / Stat3 / TGF‐β / ライブイメージング

Outline of Final Research Achievements

Cleft lip and palate is the most common morphogenetic phenomenon that occurs in the maxillofacial region in humans, and can be caused by significant effects on genetic and environmental factors. In particular, it has been clarified that the dyskinesia of the palatal process epithelium is closely related to the development of cleft palate. In this study, we clarified the effect of the Stat3-TGFβ signaling pathway involved in secondary palatal fusion on the dynamics of medial edge epithelium cells.

Free Research Field

歯科矯正学

Academic Significance and Societal Importance of the Research Achievements

TGF-βシグナル伝達経路は口蓋裂発症において中心的な役割を果たしていることは知られているものの、口蓋上皮の細胞動態に与える影響やその分子メカニズムについては不明な点が多い。本研究で明らかとなった口蓋突起癒合面上皮細胞に対するStat3-TGFβシグナルの細胞動態解析は口蓋裂の新たな治療法・予防法の開発に寄与することが期待される。