The relationship between primary cilia and environmental factors during tooth development

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K19305
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57070:Developmental dentistry-related
• Research Institution: Kanazawa University (2022); Fukuoka Dental College (2019-2021)
• Principal Investigator: OGATA Kayoko 金沢大学, 医学系, 助教 (70830123)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: MIM / 形成異常 / 歯

Outline of Final Research Achievements

In recent years, it was reported that a new type of localized abnormal tooth root morphology, Molar-root incisor malformation (MIM). MIM showed root abnormality of regional teeth such as permanent first molars (PFM) and incisors. However, the mechanism of MIM symptoms remains unclear.
We confirmed ectopic mineralization of pulp cavity in and clarified characteristics of it by histological analyses using human teeth diagnosed with MIM. We finally conclude that based on considering the result of in vitro, environmental factors during the period of developing the PFM and incisor possible cause involved in the ectopic calcification of MIM.

Free Research Field

小児歯科学　歯の発生

Academic Significance and Societal Importance of the Research Achievements

Molar-incisor malformation（MIM）のような形成異常を呈する歯は、保存が困難となり早期に抜歯が必要となる場合があり、成長発達期である小児においては健全な口腔機能の獲得に不利となる。本研究により、MIMの歯に現れる異所性石灰化の原因として、第一大臼歯や切歯の形成時期である出生時や出生後早期の環境因子が関与している可能性が示唆された。この成果は、MIMの原因解明へ向けた端緒となると考えられる。