2021 Fiscal Year Final Research Report
Carcinogenic potential of boron
| Project/Area Number |
19K19408
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 58020:Hygiene and public health-related: including laboratory approach
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| Research Institution | Meijo University (2021)
Nagoya University (2019-2020) |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | ホウ素 / 発癌 |
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| Outline of Final Research Achievements |
Our study demonstrated high levels of boron in well drinking water though environmental monitoring in Kabul, Afghanistan. Both the mean and maximum boron concentrations in drinking water collected from Afghanistan were generally higher than those in other countries previously reported. Our results indicate that Kabul in Afghanistan is one of the areas with highest levels of boron pollution in the world.
In addition, our cellular physiological results and biochemical study demonstrated that boron at concentrations of 50-500 uM boron promotes malignant transformation in nontumorigenic cells with activation of the carcinogenic pathway of c-SRC and PI3K/AKT pathway, suggesting a potential carcinogenic risk of exposure to boron.Therefore, in the future, the epidemiological study is needed to clarify the health risk for the residents in Kabul, Afghanistan exposed to high levels of boron from drinking water.
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| Free Research Field |
環境毒性学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は、アフガニスタン・カブールの飲用地下水227検体を用いた独自の元素分析結果を基にしている。本研究が証明した、ホウ素によるin vitro発癌毒性は世界で初めての報告であり、今後ホウ素の世界的な飲料水基準値の見直しのための必要不可欠の情報となると考えている。
日本では、ホウ素が100mg/Lを超える濃度含まれる温泉水もあり、温泉水の「飲泉」や農業利用が進む現状において、早急にホウ素の毒性を明らかにしておくことが必要である。また同時に、汚染水を浄化し安全な水の確保のための方法を開発する必要がある。
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